Ph.D. Position in Improving Nanoparticulate Carriers for Oral Drug Delivery Using Archaeal Lipids
The Department of Biology at SDU is seeking a highly motivated candidate to work on a project that aims to improve nanoparticulate carriers for oral drug delivery by using archaeal lipids (preferably) starting in February 2019.
Application deadline: 18 January 2019.
Most modern protein or peptide drugs suffer from premature degradation and poor permeability when administered orally. Nanoparticulate drug carriers like phospholipid vesicles (liposomes) show great promise in protecting these drugs on their passage through the gastrointestinal tract to the site of absorption. To further improve liposomes for this application, membrane lipids from species of the domain Archaea have been used. Obtaining sufficient amounts of these lipids has so far been challenging and costly, therefore project aims to explore alternative sources.
The experiments for this interdisciplinary project will require skills in the generation of biomass, the extraction of lipids, liposome preparation and stability testing as well as in studying the oral bioavailability in animal models. Therefore SDU seeks a candidate with a background in either microbiology or pharmacy, with preferably practical experiences in the cultivation of microorganisms, lipid extraction and purification and liposome preparation and characterization. Documented hands-on experience with relevant preparative and analytical techniques, especially liposome preparation, photon correlation spectroscopy and flow field-flow fractionation in conjunction with multi-angle laser light scattering are regarded as advantageous. As the Department of Biology at SDU is an international work environment, good skills in communicating in English are required.
The Ph.D. position is externally financed and the applicant is expected to accept the conditions resulting from this construct, among which are contribution towards progress reports (oral & written) to Phospholipid Research Center (Heidelberg, Germany) and part-time work as an editorial assistant for European Journal of Pharmaceutical Sciences (Elsevier, Amsterdam Netherlands).
The project is located at the Department of Biology (SDU) and will be carried out in close collaboration between the groups of Professor Martin Brandl (Department of Physics, Chemistry and Pharmacy, SDU) and Associate Professor Alexander Treusch (Department of Biology, SDU). For further information please contact Alexander Treusch, e-mail: firstname.lastname@example.org.
Appointment as a Ph.D. Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.
The successful applicant will be employed in accordance with the agreement of 10 November 2015 on salaried Ph.D. scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the Ph.D. Programme at the Universities (Ph.D. order).
The University wishes SDU staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Application must be made in the form of a Declaration of Interest including the following:
- A research proposal/description of your approach to the above project (max one page excluding references)
- A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages) (please attach this under box “Application form”)
- Detailed CV, including personal contact information
- Copies of diplomas, Bachelor as well as Master’s degree, including the transcript of notes/grades
- At least two signed reference letters. Should your referees wish to send their letters directly to SDU, please have them use e-mail: email@example.com mentioning your name and the title of the position in the subject line. And please note that these also need to reach SDU before the deadline.
Shortlisting may be used in the assessment process.
Further information about the PhD-study can be found at the homepage of the University.
Applications must be submitted electronically using the link “Apply online”. Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. SDU strongly recommend that you read How to apply before you apply.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.
You can apply for the job at The Faculty of Science by completing the application form